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Vitamin B7

WATER-SOLUBLE

Biotin-lysine complexes (biocytin)

Biotin (vitamin B7) functions as a cofactor for carboxylase enzymes involved in fatty acid synthesis, gluconeogenesis, and the catabolism of branched-chain amino acids. Biotin also regulates gene expression through its binding to histones, where it may influence chromatin structure and DNA repair. The body obtains biotin from dietary sources and from synthesis by bacteria in the large intestine. Raw egg whites contain avidin, a protein that binds biotin and prevents its absorption.

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Key Functions

  • Fatty acid synthesis
  • Gluconeogenesis
  • Amino acid catabolism
  • Gene expression regulation
  • DNA repair via histone binding

Best Food Sources

Egg yolks and liverNuts and seedsSalmon and avocadoSweet potatoes

Deficiency: Biotin Deficiency

  • Hair loss (alopecia)
  • Scaly red rash (around eyes, nose, mouth)
  • Conjunctivitis
  • Depression and lethargy
  • Neurological symptoms

High-Risk Groups

  • People consuming raw egg whites regularly
  • Those on long-term antibiotic therapy
  • Pregnant and breastfeeding women

Reviewed for accuracy: Content is based on guidelines from the NIH Office of Dietary Supplements, Harvard T.H. Chan School of Public Health, and peer-reviewed medical literature.

Recommended Daily Amount

Adult Men

30 mcg

Adult Women

30 mcg

Did You Know?

Raw egg whites contain avidin, a protein that binds biotin with extremely high affinity. Cooking denatures avidin and eliminates this effect.

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